Correlation of spot urine protein-creatinine ratio with 24-hour urinary protein in type 2 diabetes mellitus patients: a cross sectional study
Journal of Research in Medical Sciences, 06/06/2011
Biradar SB et al. – The random urine P:C ratio predicts the amount of 24–hour urinary protein excretion with high accuracy. Hence it can be used as a faster diagnostic substitute for 24–hour urinary protein estimation.
Methods- This study was conducted amongst 42 diabetic subjects from HSK hospital, Bagalkot.
- Twenty four–hour urine protein and random urine protein to creatinine ratio (P:C) was determined.
- Pearson’s correlation, sensitivity, specificity, positive and negative predictive values were determined using 24–hour urinary protein as a gold standard for spot urine P:C ratio.
- ROC curve and area under curve was also determined using SPSS (11.5) software.
- All the results were expressed in mean±SD.
- Forty two diabetes mellitus patients participated in this study.
- The average of 24 hour urinary protein was 1.6 ± 1.7 gm/day.
- The spot urine P:C ratio was 1.27 ± 1.55.
- There was a positive correlation between 24 hours urinary protein and spot urine P:C ratio (r = 0.925, p < 0.0001).
- The area under the ROC curve for urine P:C ratio at various cutoff was 0.947 (95% confidence interval: 0.831–0.992, p < 0.0001).
- The sensitivity and specificity was 80.65% and 100% respectively at P:C ratio cutoff of 0.3.
