Fischer K et al. – The results indicate that advanced renal cancers are accompanied by increased levels of acute–phase proteins such as C–reactive protein (CRP) and SAA. Serum amyloid A (SAA) is found to be more sensitive than CRP for the indication of advanced renal cancer.
In thestudy, 48 patients with localized and 67 patients with advanced renal tumors were included.
24 patients served as a control group.
Interleukine 6 (IL-6), C-reactive protein (CRP) and SAA levels were measured preoperatively and at day 5 after nephrectomy.
The IL-6, CRP and SAA levels in patients with advanced tumors are significantly higher than those of patients with localized tumors.
Advanced tumors were identified with a sensitivity of 78% (SAA), 69% (CRP) and 44% (IL-6).
The specificity was 82%, 82% and 94% for SAA, CRP and IL-6, respectively.
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