Risk of Herpes Zoster in CKD: A Matched-Cohort Study Based on Administrative Data

American Journal of Kidney Diseases, 05/11/2012

This population–based cohort study indicated that patients with chronic kidney disease are at increased risk of herpes zoster compared with the general population.


  • Data from the Taiwan Longitudinal Health Insurance Database (LHID) for 2004-2006 were analyzed.
  • The study cohort included patients 18 years or older given a diagnosis of CKD (excluding patients treated by dialysis or transplant) in 2004-2005 (n = 13,321).
  • The comparison cohort (n = 66,605) included 5 randomly selected age- and sex-matched controls for each patient in the study cohort.
  • Incident cases of CKD were identified using the Taiwan LHID.
  • CKD was ascertained from International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes.


  • Herpes zoster, ascertained from ICD-9-CM codes.
  • All participants were followed up from the date of cohort entry until they developed herpes zoster or the end of 2006.
  • Cox proportional hazard regressions were performed to compare the hazard rates of herpes zoster in the CKD cohort and the age- and sex-matched comparison cohort.

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