Investigation of recurrent deletion loci specific to conventional renal cell carcinoma by comparative allelotyping in major epithelial carcinomas

Indian Journal of Urology, 04/13/2012

The authors' findings suggested fragile histidine triad (FHIT) deletion as an early and Von–Hippal Lindau (VHL) deletion as an early and/or late event in cRCC. Additionally, studies also disclosed the recurrent deletions of flanking loci to FHIT and VHL in conventional renal cell carcinoma (cRCC). The dilemma of interstitial or continuous deletion on 3p needs to be resolved by implementation of latest sensitive molecular techniques that would further help to narrow down search for tumor suppressor gene loci specific to cRCC, other than VHL and FHIT.

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