Statin use and the risk of renal cell carcinoma in 2 prospective US cohorts

Cancer, 07/14/2011

Liu W et al.– The current study indicated that statin use may be associated with a lower risk of renal cell carcinoma (RCC) in women, although these results need to be investigated further.

Methods

  • The authors investigated the association between statin use and RCC risk in the Nurses' Health Study and Health Professionals Follow–Up Study.
  • In total, 80,782 women and 37,869 men were followed for 14 years and 16 years, respectively.
  • Regular statin use was assessed at baseline and was updated biennially during follow–up. RCC diagnosis was confirmed by medical record review.

Results

  • Two hundred seventy–seven incident RCC cases (164 women and 113 men) were identified.
  • Compared with no current use, the multivariate relative risks of current statin use were 0.68 (95% confidence interval, 0.46–1.00) in women and 1.17 (95% confidence interval, 0.75–1.82) in men.
  • The results for ever versus never users of statins were similar.
  • No dose–response relation with duration of statin use and RCC risk was observed.
  • On subgroup analyses, statin use was associated with a reduced RCC risk among women who had no history of hypertension.

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