Dynamics of Senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis
Cancer Research, May 2, 2013
Tokarsky-Amiel R et al. - Cellular senescence, a state of cell-cycle arrest accompanied by dramatic morphologic and metabolic changes, is a central means by which cells respond to physiologic stress and oncogene activity. Senescence is thought to play important roles in aging and in tumor suppression, yet the dynamics by which senescent cells are formed, their effects on tissue function and their eventual fate are poorly understood. The findings provide basic insights into ...
Renoprotective effect of Alpiniae oxyphyllae Fructus on ischemia/reperfusion-induced acute renal failure
Archives of Pharmacal Research, May 9, 2013
Kim EJ et al. - The present study was designed to examine whether water extract of Alpiniae oxyphyllae Fructus (AAO) has an effect on renal functional parameters in association with the expression of water channels and sodium potassium pump in ischemia/reperfusion-induced acute renal failure (arf). Taken together, the present study suggested that A. oxyphyllae ameliorates the urine concentration and renal functions in ischemia/reperfusion-induced arf, through the restoring of ...
Chimeric negative regulation of p14ARF and TBX1 by a t(9;22) translocation associated with melanoma, deafness and DNA repair deficiency
Human Mutation, May 10, 2013
Tan X et al. - Authors characterized a novel balanced t(9;22)(p21;q11.2) translocation in a patient with melanoma, DNA repair deficiency, and features of DiGeorge syndrome (DGS) including deafness and malformed inner ears. Using chromosome sorting we located the 9p21 breakpoint in CDKN2A intron 1. Expression of the chimera in normal cells produced dominant negative inhibition of p14arf. Similar chimeric mRNAs may mediate haploinsufficiency in DGS or dominant negative inhibition of other ...
Invasive Meningococcal Infection: Analysis of 110 cases from a Tertiary Care Centre in North East India
The Indian Journal of Pediatrics, May 6, 2013
Hazarika RD et al. - To report an outbreak of invasive meningococcal disease from Meghalaya, in the north east India, from January 2008 through June 2009. This is the first epidemic report of invasive meningococcal disease from the north east India. Chloramphenicol acts well in areas with penicillin or cephalosporin resistance. Mortality reduces significantly with early diagnosis and prompt intervention. Methods Retrospective review of case sheets was done. One hundred ten ...
P14ARF Is Down-regulated During Tumour Progression and Predicts the Clinical Outcome in Human Breast Cancer
Anticancer Research, May 6, 2013
Wazir U et al. - The objective of this study was to determine the mRNA expression for p14 and p16 in a cohort of women with breast cancer. p14 expression seems to increase initially in early breast cancer and decrease with further tumour progression. p14 may be induced to counteract immortalisation and hTERT surge.
Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck
Carcinogenesis, May 8, 2013
Jin L et al. - Because of their important roles in mediating the stabilization and expression of p53, the authors hypothesized that high-risk genotypes of polymorphisms in p53-related genes, including p53, p73, p14arf, MDM2 and MDM4, may be associated with an increased risk of second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN). This findings suggest that combined risk genotypes of p53-related genes may jointly modify SPM ...