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English K et al. – In accordance with recent mechanistic advances, the authors recommend an applied, broad–based two–phase approach to limit inactivity–mediated losses of muscle mass and function in older adults: (i) Lifestyle: consume a moderate amount (25–30 g) of high–quality protein with each meal and incorporate habitual exercise in close temporal proximity to protein–containing meals; (ii) Crises: react aggressively to combat the accelerated loss of muscle mass and function during acute catabolic crises and periods of reduced physical activity. As a base strategy, this should include nutritional support such as targeted protein or amino acid supplementation and integrated physical therapy.


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