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See Latest ArticlesRosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts
Rheumatology, 12/11/09
Shi-wen X et al. – The transcription factor peroxisome proliferator-activated receptor (PPAR)- plays an important role in controlling cell differentiation. The aim of the present study was to examine whether PPAR- expression was reduced in skin scleroderma fibroblasts and whether PPAR- agonists could suppress the persistent fibrotic phenotype of skin scleroderma fibroblasts. Rosiglitazone may alleviate the extent of fibrosis in dcSSc. E
Methods- Dermal fibroblasts were isolated from site-, age- and sex-matched healthy individuals and lesional areas of individuals with dcSSc.
- Western blot and collagen gel contraction analyses were used to detect protein expression in the presence or absence of the PPAR- agonist rosiglitazone
- PPAR- expression was reduced in dcSSc fibroblasts. The PPAR- agonist rosiglitazone alleviated the persistent fibrotic phenotype of dcSSc fibroblasts
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