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Blood pressure and risk of prostate cancer: Cohort Norway (CONOR)
Cancer Causes and Control, 12/07/09
Martin RM et al. – Some studies suggest that raised blood pressure may increase prostate cancer risk. We investigated associations of blood pressure with prostate cancer within the CONOR collaborative cohorts of Norway. Raised blood pressure was associated with an increased risk of prostate cancer, particularly advanced cancers at diagnosis.
Methods- Between 1994 and 2003, 82,098 men from 10 population-based cohorts in Norway completed standardised questionnaires and physical examinations, including resting BP
- Unique 11-digit identification number of Norwegian citizens allowed linkage with Cancer Registry of Norway
- Total of 78,768 (96%) men who were cancer-free at baseline and average age of 50.3 years (standard deviation, SD: 15.2) followed up for a mean of 9.15 years. 11.4% of these men used antihypertensive drugs at baseline
- During follow-up (1994–2006), 1,974 incident prostate cancers diagnosed
- 4% (95% confidence interval, CI = 0–9%) increased risk of prostate cancer per one SD (18.3 mmHg) increase in systolic blood pressure and similar findings for diastolic blood pressure (hazard ratio, HR: 1.05 per SD; 95% CI = 1.01–1.10)
- Association stronger for advanced (HR: 1.16 per SD increase in systolic blood pressure; 95% CI = 1.05–1.27) compared with localised (1.01; 0.95–1.08) prostate cancer (p for heterogeneity in hazard ratios = 0.02)
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