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See Latest ArticlesInfluence of NFkB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC
International Journal of Colorectal Disease, 11/24/09
Raddatz D et al. – The data explain the frequent unresponsiveness of IBD to glucocorticoid treatment and suggest that alternative NFkB inhibition in IECs might be of use in IBD therapy. Drug development based on measuring anti–NFkB activity might be misleading and should therefore also include studies on relevant gene products.
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