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Mechanisms By Which Sleep Disturbance Contributes to Osteoarthritis Pain: A Conceptual Model
Current Pain and Headache Reports, 11/06/09
Smith MT et al. – This article reviews the extant literature on sleep disturbance and hyperalgesia in patients with OA. The authors propose a conceptual working model describing pathways by which sleep disturbance interacts directly with central pain processing mechanisms and inflammatory processes, and indirectly with mood and physical functioning to augment clinical OA pain. The clinical and research implications of the model are discussed.
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