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Is the course of gastroesophageal reflux disease progressive? A 21-year follow-up
Scandinavian Journal of Gastroenterology, 11/06/09
Falkenback D et al. – After 20 years a considerable part of the cohort still experienced symptoms of reflux and showed endoscopic progression, although no significant deteriorations were seen in manometry data and in most pH–metry data. H. pylori infection was inversely associated with erosive esophagitis and this supports the hypothesis that H. pylori colonization is a protective factor against GERD.
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