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S McGill et al. – The authors showed that nonpolypoid colorectal neoplasms (NP–CRNs) are relatively common and are potentially more dangerous than polypoid neoplasms of similar size because they have a higher risk of containing in situ or submucosal invasive carcinoma. Some nonpolypoid gastrointestinal neoplasms are fairly easy to detect and diagnose, whereas others can be quite difficult to visualize using white light illumination. The current technique and technology of image–enhanced endoscopy (IEE) is available to augment the detection, diagnosis and treatment of these subtle lesions.

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