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Santiago M et al. – Since there is no evidence on the prophylaxis of SHS in immunosuppressed rheumatic patients, the suggested regimen for that prophylaxis may rely on the results obtained from therapeutical studies. Ivermectin has the best safety profile, lower cost and best efficacy and should be the drug of choice for the prophylaxis of SHS in such patients. Although a definitive prophylactic regimen has not been defined, the option for 200[micro]g/kg/day for 2days, repeated within 2weeks, seems to be a reasonable approach. Such regimen should be repeated every 6months in case of persisting immunosuppression in permanent residents of endemic areas.

   

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