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See Latest ArticlesNew antiplatelet agents: Why they are needed
European Journal of Internal Medicine , 11/09/09
Franchini M et al. – The limitations of the currently available antiplatelet agents have triggered the development of newer drugs. In this review we summarize the mechanisms of actions and results of current clinical trials of novel antiplatelet agents. These include prasugrel, a thienopyridine prodrug which has a mechanism similar to that of clopidogrel but superior pharmacokinetic features; ticagrelor, a non–thienopyridine that binds reversibly to the platelet P2Y12 receptor; cangrelor, an intravenously administered analog of ticagrelor; the thrombin receptor antagonist SCH 53048; and terutroban (S18886), a thromboxane A2 receptor inhibitor.
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