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See Latest ArticlesMechanisms and Functional Implications of Intestinal Barrier Defects
Digestive Diseases, 11/06/09
Turner JR et al. – Inflammatory cytokines can cause barrier defects and, conversely, barrier defects can activate the mucosal immune system. This raises the possibility that restoration of barrier function may be therapeutic in CD. Consistent with this hypothesis, emerging data indicate that inhibition of cytoskeletally mediated barrier dysfunction may be able to prevent disease progression. Barrier restoration may, therefore, represent a non–immunosuppressive approach to achieving or maintaining disease remission.
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