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Interaction of malaria with a common form of severe thalassemia in an Asian population
Proceedings of the National Academy of Sciences of the United States of America, 11/04/09

O'Donnell A et al. – The thalassemic patients showed significant correlations between malaria antibody status and phenotype. Patients with HbE ? thalassemia may be more prone to malaria, particularly P. vivax, which is reflected in their clinical severity. Because P. vivax malaria is widespread in Asia, further studies of its interaction with HbE ? thalassemia and related diseases are required urgently as a part of ongoing thalassemia control programs.