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See Latest ArticlesProtection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of beta2-adrenoceptor
Nephrology Dialysis Transplantation, 11/05/09
Nakamura A et al. – A renal–specific over–expression of ?2–AR, resulting from gene delivery, appeared to modulate renal dysfunction and inflammation following sepsis by altering cAMP–PKA, CB–1 and CD14–TLR4–TNF– pathways. In addition, gene delivery and activation of ?2–AR produced modulation of systemic NO and Ang II, which further protected against renal dysfunction. Administration of the Adeno–?2–AR gene has potential as a therapeutic agent against ARF following the onset of sepsis.
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