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Apana SM et al. – This in turn required a cigarette formulated with carbon–11 labeled nicotine suitable for administration by single bolus inhalation. Here authors report the development and validation of cigarettes formulated with [11C]nicotine that were successfully used for single bolus administration by smoking. The authors also report measurements of nicotine delivery from smoked cigarettes.

Exclusive Author Commentary
M. S. Berridge, 11/02/09

Formulation of radiolabeled cigarettes allows smoked administration of nicotine for PET scanning. These were used later in a study relevant to the question of nicotine addiction.

   

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