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See Latest ArticlesPeripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line
Journal of Leukocyte Biology, 11/09/09
Bahbouhi B et al. – The frequency of PSGL–1 was unchanged in CD8+ cells from MS patients, whereas CD8+LFA–1high were reduced significantly in IFN–[beta]–treated patients specifically. Collectively, MS is associated with an expanding pool of PSGL–1+CD4+ T lymphocytes able to transmigrate the BBB endothelium in vitro and possibly contributing to brain pathology.
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