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Three-Year Efficacy of Complex Insulin Regimens in Type 2 Diabetes
New England Journal of Medicine, 10/29/09
Holman RR et al. – Patients who added a basal or prandial insulin–based regimen to oral therapy had better glycated hemoglobin control than patients who added a biphasic insulin–based regimen. Fewer hypoglycemic episodes and less weight gain occurred in patients adding basal insulin.
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