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See Latest ArticlesCIS is a surrogate marker of genetic instability and field carcinogenesis in the urothelial mucosa
Urologic Oncology: Seminars and Original Investigations, 10/27/09
Palmeira C et al. – This study points out that CIS is a marker of genetic instability of the urothelium mucosa. The CIS surrounding morphologically normal urothelium showed a high frequency of abnormal DNA content, with high percentage of clear aneuploid cells (high 5cER), p53 mutated protein expression, and a proliferative status underlying a field carcinogenesis. These alterations in normal mucosa were not found when CIS was not present.
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