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Repeated low-dose skin exposure is an effective sensitizing stimulus, a factor to be taken into account in predicting sensitization risk
British Journal of Dermatology, 10/26/09
Paramasivan P et al. – The same degree of sensitization was induced by three exposures to DNCB 10 microg cm-2 as by one exposure to 60 microg cm-2 of DNCB. Thus repeated exposure to low doses of contact sensitizers may increase the sensitizing potency. This must be taken into account in future risk assessments.
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