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Regulation of lipid metabolism by energy availability: a role for the central nervous system
Obesity Reviews, 11/06/09

Nogueiras R et al. – In this review, the authors mainly focus on how neuronal circuits within the hypothalamus, such as leptin– ghrelin–and resistin–responsive neurons, as well as melanocortins, neuropeptide Y, and the cannabinoid system exert their actions on lipid metabolism in peripheral tissues such as WAT, liver or muscle. Dissecting the complicated interactions between peripheral signals and neuronal circuits regulating lipid metabolism might open new avenues for the development of new therapies preventing and treating obesity and its associated cardiometabolic sequelae.

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