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Guiding clinical decisions on abdominal obesity and cardiometabolic risk
Clinical Cornerstone, 10/22/09

Nesto RW et al. – Studies have shown that obesity increases cardiometabolic risk across the span of life. Obesity results in increased production of proinflammatory adipokines and decreased production of the anti–inflammatory adi–pokine, adiponectin, which eventually leads to atherosclerosis and type 2 diabetes mellitus. Lifestyle changes are the cornerstone for treatment of overweight and obese patients; however, pharmacotherapy and surgery are 2 additional treatment options that may be considered when lifestyle changes alone are unsuccessful. Adipose tissue, particularly central adipose tissue, is an endocrine organ, the actions of which tie together all components of cardiometabolic risk. Weight loss reduces levels of most proinflammatory adipokines, attenuates inflammation, improves endothelial function, and enhances insulin sensitivity.

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Early life influences on obesity risk: maternal overnutrition and programming of obesity
Expert Review of Endocrinology & Metabolism, 11/12/09 Relevance Score: 69%

Obesity may top hypertension as risk factor for LA enlargement
Internet Source, 11/11/09 Relevance Score: 69%

Overweight and obesity: The pathogenesis of cardiometabolic risk
Clinical Cornerstone, 10/23/09 Relevance Score: 69%

Vascular health in children and adolescents: effects of obesity and diabetes
Vascular Health and Risk Management, 11/11/09 Relevance Score: 68%

Common mental disorder and obesity: insight from four repeat measures over 19 years: prospective Whitehall II cohort study
British Medical Journal, 10/28/09 Relevance Score: 68%