Med Student Medical News about Pilocytic Astrocytomas

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In pursuit of prognostic factors in children with pilocytic astrocytomas
Child's Nervous System, 10/29/09

Becker AP et al. – Aside from GTR, no other clinical, histopathological, or immunohistochemical features were found to be related to the prognosis. The authors postulate that strict follow–up is recommended if piloA is associated with high mitotic activity/Ki67–LI, or if GTR cannot be achieved at surgery. Tumor recurrence or progression of the residual lesion should be strictly observed. In some aspects, childhood piloA remains an enigmatic tumor.

Exclusive Author Commentary
Ricardo Santos de Oliveira, 10/29/09

Aside gross tumor resection no clinical or microscopic factors were significantly related to patients’ outcome. In some aspects, pilocytic astrocytoma in children remains an enigmatic tumor. Further series with molecular studies focused on the genetic alterations can offer a better comprehension of the pathobiology of these tumors and are highly expected.

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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma
Neurology, 10/13/09 Relevance Score: 67%

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain Tumors
Brain Pathology, 11/11/09 Relevance Score: 66%

Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor
Journal of Neuro-Oncology, 10/30/09 Relevance Score: 66%

Impact of Morphology, MIB-1, p53 and MGMT on Outcome in Pilocytic Astrocytomas
Brain Pathology, 10/20/09 Relevance Score: 65%

Diagnostic and prognostic markers in gliomas
Current Opinion in Oncology, 10/13/09 Relevance Score: 64%