Med Student Medical News about Diabetes Mellitus, Type 2 Insulin

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Once-daily initiation with biphasic insulin aspart 30 versus insulin glargine in patients with type 2 diabetes inadequately controlled with oral drugs: an open-label, multinational RCT
Current Medical Research and Opinion, 10/22/09

Strojek K et al. – With respect to HbA1c, BIAsp 30 fulfilled the statistical criteria for non–inferiority and superiority to insulin glargine and, according to pre–defined criteria, the improvements in HbA1c are considered clinically equivalent. Subjects had an increased risk of minor nocturnal hypoglycemia with BIAsp 30. There were no differences in treatment satisfaction between the two groups.

Exclusive Author Commentary
Krzysztof Strojek, 10/22/09

Hypoglycemic treatment of type 2 diabetic patients must be focused on normalization of blood glucose without adverse effects. The study showed that initiation of insulin should be individualized. Both algorithms brought the similar treatment satisfaction while BIAsp30 was associated with better glycemic control. On the other hand in the group of patients with higher risk of hypoglycemia, especially nocturnal, insulin initiation with glargine should be considered as alternative option.

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