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New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome
Current Rheumatology Reports, 10/09/09

Magrey M et al. – Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. The newly available whole–body MRI will assist early diagnosis by detecting multifocal osteitis lesions, some of them asymptomatic, in axial (anterior chest wall, spine, and jaws) and nonaxial sites. Moreover, outcomes are vastly improved by treatment with bisphosphonates and tumor necrosis factor–alpha antagonists.

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