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Adjuvant radiotherapy and chemoradiation after surgery for cervical cancer
Cochrane Reviews, 10/09/09

Rogers L et al. – The authors found only two trials that compared the use of radiotherapy with no radiotherapy in women with early cervical cancer who had their womb and pelvic lymph nodes removed and who were at risk of having a recurrence of their cancer. These two trials enrolled 397 women. When the authors combined the findings from these two trials, the authors found that, on average, women who received radiotherapy were between 40% and 90% less likely to have a relapse of their cancer within five years than women who did not. However, because of the low number of deaths in the trials, the authors could not confirm whether radiotherapy helped to prolong life: the authors' best estimate was that, five years after treatment, women who received radiotherapy were about 20% more likely to be alive than those who did not, but this estimate may not be very accurate and women's actual prospects could be anywhere between being three times more likely to be alive and being 60% more likely to be dead. Although women who had radiotherapy tended to have more complications than women who did not, the authors couldn't be sure whether this was due to chance rather than the radiotherapy because few women reported complications.

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