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See Latest ArticlesCystatin C is a sensitive marker for detecting a reduced glomerular filtration rate when assessing chronic kidney disease in patients with rheumatoid arthritis and secondary amyloidosis
Scandinavian Journal of Rheumatology , 10/02/09
Sato H et al. – Serum cysC can identify a reduced GFR more accurately than sCr-eGFRs. Serum cysC > 1.09 mg/L could be a marker of a reduced GFR, and serum cysC > 1.365 mg/L would strongly suggest a reduced GFR in patients who have RA with secondary amyloidosis.
Methods- 50 patients with RA and secondary amyloidosis (mean age 60.9 ± 11.2 years; 45 women) were evaluated
- Revised 24-h creatinine clearance (r24-hCCr), was determined by multiplying original value by 0.719, used as reference for GFR
- Screening potential of serum cysC and some estimates of GFR calculated from serum cysC (cysC-eGFR: eGFRHoek and eGFRRule) for detecting reduced GFR analysed
- Both cysC-eGFRs strongly correlated with r24-hCCr
- Difference between the eGFRRule and average r24-hCCr was small
- eGFRHoek and sCr-eGFR were higher than eGFRRule and r24-hCCr
- In receiver operating characteristic (ROC) curve analyses of reduced GFR, serum cysC gave a greater area under curve than the sCr-eGFR
- Specificity and PPV 100% when serum cysC > 1.365 mg/L was used
Today in Chronic Dz/Renal Failure...keeping you current
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Today in Glomerular/Tubular Dz...keeping you current
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Membranous (Class V) Renal Disease in Systemic Lupus Erythematosus May Be More Common Than Previously Reported: Results of a 6-Year Retrospective Analysis
The American Journal of the Medical Sciences, 03/18/10
Successful treatment of steroid-resistant nephrotic syndrome associated with WT1 mutations
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Today in Amyloidosis...keeping you current
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A case of emphysematous pyelonephritis in a patient with rheumatoid arthritis taking corticosteroid and low-dose methotrexate
International Journal of Rheumatic Diseases, 03/10/10
Elevated levels of the acute-phase serum amyloid are associated with heightened lung cancer risk
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Today in Basic Science/Genetics...keeping you current
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Decreased circulating CD28-negative T cells in patients with rheumatoid arthritis treated with abatacept are correlated with clinical response
Journal of Rheumatology, 03/19/10
Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease
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American Journal of Epidemiology, 03/19/10
Today in Rheumatoid Arthritis...keeping you current
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Rheumatoid arthritis and autoimmune hemolysis: B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease
Zeitschrift für Rheumatologie, 03/19/10
Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA
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Risk factor profiles for atherosclerotic cardiovascular disease in Black and other Africans with established rheumatoid arthritis
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