Med Student Medical News about Methadone Pain, Postoperative Clonidine

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Efficacy of intraoperative methadone and clonidine in pain control in the immediate postoperative period after the use of remifentanil
Revista Brasileira de Anestesiologia, 09/23/09

Simoni RF et al. – The incidence of pain in the methadone group was significantly lower than in the clonidine and placebo groups (11, 21, and 23, respectively; p < 0.02). Significant differences in the incidence of pain in the placebo and clonidine groups were not observed. Methadone was more effective than clonidine in the control of postoperative pain in videolaparoscopic surgeries under total intravenous anesthesia with remifentanil; and using clonidine was not better than not using it.