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Komiya K et al. – The authors demonstrate the expression of TNF–alpha converting enzyme, TNF–alpha and matrix metalloproteinase–3 in SAPHO syndrome synovitis for the first time and also show, both macro– and microscopically, the similarity between SAPHO syndrome and rheumatoid arthritis synovitis. These new findings support the recently reported successful treatment of SAPHO syndrome with antirheumatic drugs, especially with anti–TNF–alpha agents.


   

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