Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Use of Antiemetic Agents in Acute Gastroenteritis 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease
Your Article Summary
See Latest ArticlesS(+)-ketamine Effect on Experimental Pain and Cardiac Output: A Population Pharmacokinetic-Pharmacodynamic Modeling Study in Healthy Volunteers
Anesthesiology, 09/14/09
Sigtermans M et al. – Low–dose ketamine behaves as an analgesic in the treatment of acute and chronic pain...Sex differences observed were restricted to pharmacokinetic model parameters, with a 20% greater elimination clearance of S(+)–ketamine and S(+)–norketamine in women resulting in higher drug plasma concentrations in men. S(+)–ketamine produced profound drug high and analgesia with six times greater potency in the heat pain than the electrical pain test. After ketamine–infusion, analgesia rapidly dissipated; in the heat pain test but not the electrical pain test, analgesia was followed by a period of hyperalgesia. Over the dose range tested, ketamine produced a 40–50% increase in cardiac output. A significant consistent contribution of S(+)–norketamine to overall effect was detected for none of the outcome parameters. S(+)–ketamine displays clinically relevant sex differences in its pharmacokinetics. It is a potent analgesic at already low plasma concentrations, but it is associated with intense side effects.
Today in Anesthesia...keeping you current
Receive free subspecialty "5-minute updates" via email
Postoperative gastrointestinal tract dysfunction: An overview of causes and management strategies
Cleveland Clinic Journal of Medicine, 12/04/09
Perioperative care of the elderly patient: An update
Cleveland Clinic Journal of Medicine, 12/04/09
Postoperative pulmonary complications: An update on risk assessment and reduction
Cleveland Clinic Journal of Medicine, 12/04/09
Sponsor
Article Search
Sponsor