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Liberati A et al. – The PRISMA Statement consists of a 27–item checklist and a four–phase flow diagram. The checklist includes items deemed essential for transparent reporting of a systematic review. In this Explanation and Elaboration document, the authors explain the meaning and rationale for each checklist item. For each item, the authors include an example of good reporting and, where possible, references to relevant empirical studies and methodological literature. The PRISMA Statement, this document, and the associated Web site (www.prisma–statement.org) should be helpful resources to improve reporting of systematic reviews and meta–analyses.

   

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