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Intracranial tumors in first year of life: the CHEO experience
Child's Nervous System, 07/01/09

Mehrotra N et al. - Brain tumors in the first year of life represent 4.8% of patients treated at CHEO. Mode of presentation, utilization of adjuvant therapy, and survival depend on tumor location and histology, with worse prognosis for infratentorial lesions. One third of patients had acceptable functional outcome requiring no special assistance.

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Michael Vassilyadi, 07/03/09

Brain tumors are rarely diagnosed in infancy with small institutional case series defining the bulk of the collective literature experience. Marked heterogeneity exists among these studies for histological diagnosis and management strategy, reflecting the varied modes of patient presentation and survival, surgeon experience and surgical decision-making, and the small lesion numbers accessible for analysis. The histological variability between different series likely accounts for survival ranging as low as 32% and as high as 81%; our long-term survival rates are in the middle of this range. The mode of presentation, utilization of adjuvant therapy, and survival are all dependent on tumor location and histology, with worse prognosis for infratentorial lesions. One third of patients in this series had excellent Karnofsky outcomes with no requirement for assisted living, with 7 out of 8 of these having had supratentorial tumors.

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