Your Article Summary
See Latest ArticlesLipid-altering efficacy and safety of ezetimibe/simvastatin versus atorvastatin in patients with hypercholesterolemia and the metabolic syndrome (from the VYMET study)
The American Journal of Cardiology, 06/22/09
Robinson JG et al. – Ezetimibe/simvastatin (E/S) is more likely to result in lipid treatment endpoints than atorvastatin and was generally well tolerated at the compared doses.
Methods- Double-blind, randomized, 6-week study of lipid-lowering efficacy of E/S 10/20 mg vs atorvastatin 10 or 20 mg, and E/S 10/40 mg vs atorvastatin 40 mg
- Subjects: 1,128 pts with hypercholesterolemia and the metabolic syndrome
- Primary endpoint: percentage of change from baseline in low-density lipoprotein (LDL) cholesterol
- Additional endpoints: changes in other lipids, lipoprotein ratios, high-sensitivity C-reactive protein, and attainment of pre-specified lipid levels
- Significantly greater improvements in levels of LDL cholesterol, non–high-density lipoprotein cholesterol, apolipoprotein B, and lipid/lipoprotein ratios with E/S vs atorvastatin at all dose comparisons
- Attainment of prespecified LDL cholesterol and non–high-density lipoprotein cholesterol levels significantly greater with E/S vs atorvastatin at all dose comparisons
- High-density lipoprotein cholesterol increases significantly greater with E/S 10/20 mg vs atorvastatin 10 mg and E/S 10/40 mg vs atorvastatin 40 mg
- Changes in triglycerides, very low-density lipoprotein cholesterol, and high-sensitivity C-reactive protein similar for both treatments
- Low incidence of liver, muscle, and gastrointestinal-, hepatitis- and allergic reaction/rash-related adverse events, generally similar to those in previous studies of E/S and/or atorvastatin
Today in Atherosclerosis/Lipids...keeping you current
Receive free subspecialty "5-minute updates" via email
Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: Results of the ICARIA study
Atherosclerosis, 12/04/09
Altered composition of triglyceride-rich lipoproteins and coronary artery disease in a large case–control study
Atherosclerosis, 12/04/09
Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia
Atherosclerosis, 12/04/09
Today in Pharmacology/kinetics...keeping you current
Receive free subspecialty "5-minute updates" via email
The association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case-control study
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 12/04/09
Effect of minodronic acid hydrate on hip geometry in Japanese women with postmenopausal osteoporosis
Journal of Bone and Mineral Metabolism, 12/04/09
Myxedema Coma Associated with Combination Aripiprazole and Sertraline Therapy
Annals of Pharmacotherapy, 12/03/09
Today in Atherosclerosis/Lipids...keeping you current
Receive free subspecialty "5-minute updates" via email
Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: Results of the ICARIA study
Atherosclerosis, 12/04/09
Altered composition of triglyceride-rich lipoproteins and coronary artery disease in a large case–control study
Atherosclerosis, 12/04/09
Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia
Atherosclerosis, 12/04/09
Today in Atherosclerosis/Lipids...keeping you current
Receive free subspecialty "5-minute updates" via email
Ageing and cardiovascular responses to head-up tilt in healthy subjects
Atherosclerosis, 12/04/09
Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: Results of the ICARIA study
Atherosclerosis, 12/04/09
Altered composition of triglyceride-rich lipoproteins and coronary artery disease in a large case–control study
Atherosclerosis, 12/04/09
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Cilostazol inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor expression in artery wall and neointimal region after vascular injury
Atherosclerosis, 12/04/09
Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD: a systematic review and meta-analysis
European Respiratory Journal , 12/03/09
The Cost Effectiveness and Cost Utility of Valsartan in Chronic Heart Failure Therapy in Italy: A Probabilistic Markov Model
American Journal of Cardiovascular Drugs, 12/03/09
Today in Atherosclerosis/Lipids...keeping you current
Receive free subspecialty "5-minute updates" via email
Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: Results of the ICARIA study
Atherosclerosis, 12/04/09
Altered composition of triglyceride-rich lipoproteins and coronary artery disease in a large case–control study
Atherosclerosis, 12/04/09
Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia
Atherosclerosis, 12/04/09