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Pancreatic metastasis from renal cell carcinoma: which patients benefit from surgical resection?
Annals of Surgical Oncology, 04/09/08

Zerbi A et al. - Pts with pancreatic metastases from RCC in a favorable risk grp are resection candidates, regardless of the presence of another metastatic site or multifocal pancreatic disease

Methods

Retrospective study of 36 pts with pancreatic metastasis from RCC to define surgery's role in treatment
Categorization into 3 risk grps based on modified Memorial Sloan-Kettering prognostic factors model

Results

Resective surgery in 23 pts: 11 distal pancreatectomy, 5 enucleation, 4 pancreatoduodenectomy, 2 total pancreatectomy, 1 middle pancreatectomy
No perioperative mortality; morbidity rate, 47.8%
All resection pts were in the favorable risk grp
Surgical resection excluded in 13 cases due to disease locally advanced (2 pts) or extrapancreatic (11 pts); risk in these pts was favorable (5), intermediate (7), and poor (1)
Surgical pts: 5-year actuarial survival rate, 88%; median disease-free survival, 44 mo
Non-surgical pts: 5-yr survival rate, 47%; median survival, 27 mo