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Hartmut Porst, et al. - Erectile dysfunction (ED) is a chronic disease; however, therapy is currently administered as needed with oral phosphodiesterase 5 (PDE5) inhibitors like tadalafil. Because the 17.5-h half-life of tadalafil enables therapeutic plasma levels to be sustained with daily administration, tadalafil is a good candidate for once daily dosing therapy...Conclusions: Once-a-day tadalafil 5 mg or 10 mg was well tolerated and significantly improved EF in men with ED

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