Population-based analysis of normal total PSA and percentage of free/total PSA values: results from screening cohort
Capitanio U et al. - In a study to examine the distribution of total prostate-specific antigen (tPSA) and percentage of free/total PSA (%f/tPSA) values in pts undergoing prostate cancer (PCa) screening, the results can guide clinicians regarding population-based distribution of serum tPSA and %f/tPSA values. Those values can be used for counseling, as well as in the informed consent process before prostate biopsy. Methods- Data from 4 consecutive annual PCa screening events held in Montreal, Canada were examined with respect to age, tPSA, and %f/tPSA in 3222 men.
Results- Median PSA level was 1.0 ng/mL and median %f/tPSA was 26%.
- Using the interquartile range around the median, the upper bound for tPSA was situated at 1.9 ng/mL and the lower bound for %f/tPSA was at 19%.
- The 90th percentile for median tPSA was 3.8, and the 10th percentile for median %f/tPSA was 14.
- PSA and %f/tPSA showed a relation with age.
- The 75th percentile for median tPSA level in the age category 40-49, 50-59, 60-69, and 70-79 yrs was 1.1, 1.4, 2.6, and 3.6 ng/mL, respectively.
- The 25th percentile for median %f/tPSA level in the age category 40-49, 50-59, 60-69, and 70-79 yrs was 19, 21, 18 and 19 ng/mL, respectively.
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