First-day step-down to oral outpatient treatment versus continued standard treatment in children with cancer and low-risk fever in neutropenia. A randomized controlled trial within the multicenter SPOG 2003 FN study Pediatric Blood & Cancer, 05/03/2012
Brack E et al. – In children with low–risk fever in chemotherapy–induced neutropenia (FN), the efficacy of first–day step–down to oral antimicrobial therapy with amoxicillin and ciprofloxacin in an outpatient setting was non–inferior to continued hospitalization and intravenous antimicrobial therapy. The safety of this procedure, however, was not assessable with sufficient power.