A single-nucleotide polymorphism in the MTHFR (methylene tetrahydrofolate reductase) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy Cancer, 04/27/2012

Mak RH et al. – This study showed an association between methylene tetrahydrofolate reductase (MTHFR) genotype and risk of clinically significant radiation pneumonitis (RP). Further study of MTHFR–related pathways may provide insight into the mechanisms behind RP.

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