Neurovascular Structure-adjacent Frozen-section Examination (NeuroSAFE) Increases Nerve-sparing Frequency and Reduces Positive Surgical Margins in Open and Robot-assisted Laparoscopic Radical Prostatectomy: Experience After 11 069 Consecutive Patients
European Urology, 07/27/2012
Schlomm T et al. – Neurovascular structure–adjacent frozen–section examination (NeuroSAFE) enables real–time histologic monitoring of the oncologic safety of a nerve–sparing (NS) procedure. Systematic NeuroSAFE significantly increases NS frequencies and reduces Positive surgical margins (PSMs). Patients with a NeuroSAFE–detected PSM could be converted to a prognostically more favorable negative SM status by secondary wide resection.