Tumor necrosis factor-α (TNF-α) stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma
Medical Oncology, 08/21/2012
Techasen A et al. – The findings suggest that the changes in the expression of Snail or E–cadherin might regulate Epithelial–mesenchymal transition (EMT) development in cholangiocarcinoma (CCA) resulting in promoting tumor progression. Overexpression of Snail could be used as a prognostic marker for monitoring the treatment efficiency of CCA patients.