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Elevated Interleukin-6 Concentration and Alterations of the Coagulation System Are Associated with the Development of Intraventricular Hemorrhage in Extremely Preterm Infants
Neonatology, 08/21/2012
Poralla C et al. – The association of elevated IL–6 levels with alterations of the coagulation profile and development of intraventricular hemorrhage (IVH) found in study supports the assumption of a close pathophysiological relation between inflammation and IVH.
Methods- Vitamin K-dependent coagulation factors were examined retrospectively in 132 extremely preterm infants prior to vitamin K administration at the first day of life.
- Patients were grouped according to the occurrence of IVH and serum concentration of IL-6 >/<100 pg/ml.
- Occurrence of IVH was associated with clinical diagnosis of chorioamnionitis, low gestational age, high CRIB score, air leak, catecholamine treatment, low initial hematocrit and increased serum concentration of IL-6.
- Infants developing IVH showed a diminished coagulation profile.
- Multivariable logistic regression analysis revealed decreased activity of coagulation factor VII, development of pneumothorax and low hematocrit as independent risk factors for the development of IVH.
- An increased IL-6 serum concentration was associated with a significantly decreased activity of coagulation factor VII and increased levels of fibrinogen.
