Glutamine Prevents Apoptosis in Intestinal Epithelial Cells and Induces Differential Protective Pathways in Heat and Oxidant Injury Models
Journal of Parenteral and Enteral Nutrition, 08/21/2012
Kallweit AR et al. – Glutamine (GLN) protects intestinal cells from both heat and oxidant injury. Heat shock proteins (HSPs)25, 32, and 70 levels increased with GLN during HS, but in oxidant injury, only HSP32 increased, suggesting GLN’s mechanism of protection may vary in different models of injury. In both injuries, GLN lowered the expression of CC3, indicating prevention of apoptosis may be a key mechanism by which GLN protects.