Regional distribution and molecular interaction of caveolins in bladder smooth muscle
BJU International, 08/21/2012
Sullivan MP et al. – The isoform–specific spatial distribution and distinct molecular interactions among caveolins in bladder smooth muscle (BSM) may contribute to the contractile heterogeneity of BSM cells and facilitate differential modulation of responses to local stimuli. As BSM caveolae regulate key signalling processes involved in contraction, altered expression of caveolin proteins may generate a regional imbalance in contraction/relaxation responses, thus leading to bladder dysfunction.