Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence
European Journal of Clinical Investigation, 08/17/2012
Masuda D et al. – Fasting serum apo B–48 levels significantly correlated with the prevalence of coronary artery disease (CAD).Methods
- Subjects who received a coronary angiography and did not take any lipid–lowering drugs (n = 189) were enrolled.
- Subjects with coronary artery stenosis ( ≥ 75%) were diagnosed as CAD.
- Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B–48 concentration were compared between CAD patients (n = 96) and age–, sex–, and body mass index (BMI)–matched non–CAD subjects without overt coronary stenosis (< 75%) (n = 67).
- Authors tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B–48 and other coronary risk factors (high triglyceride, low HDL–C, high HbA1c or low adiponectin levels) increased the prevalence of CAD.
- Fasting serum apo B–48 levels were significantly higher in CAD patients than in non–CAD subjects (3.9 ± 2.4 vs. 6.9 ± 2.6 μg/mL, P < 0.0001) and had the most significant correlation with the existence of CAD.
- The clustering of high fasting apo B–48 levels (> 4.34 μg/mL, the cut–off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B–48 levels.