Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes
Diabetes Research and Clinical Practice, 08/16/2012
Horowitz M et al. – Liraglutide caused decreased gastric emptying and increased reduction in bodyweight. The mechanisms of the liraglutide–induced weight–loss may involve a combined effect on energy intake and energy expenditure.Methods
- The comparative effects of liraglutide, glimepiride and placebo on energy intake, appetite, nausea, gastric emptying, antral distension, bodyweight, gastrointestinal hormones, fasting plasma glucose and resting energy expenditure (REE), were assessed in subjects with T2DM randomised to treatment A (liraglutide–placebo), B (placebo–glimepiride) or C (glimepiride–liraglutide).
- Assessments were performed at the end of each 4-week treatment period.
- Energy intake was less (NS) with liraglutide vs placebo and glimepiride, and 24-h REE was higher (NS) with liraglutide vs placebo and glimepiride.
- Fasting hunger was less (p=0.01) with liraglutide vs placebo and glimepiride, and meal duration was shorter with liraglutide (p=0.002) vs placebo.
- Paracetamol AUC0–60min and Cmax were less (p<0.01) and fasting peptide YY was lower (p≤0.001) after liraglutide vs placebo and glimepiride. Bodyweight reductions of 1.3 and 2.0kg were observed with liraglutide vs placebo and glimepiride (p<0.001).
- There were no differences on antral distension, nausea, or other gastro-intestinal hormones.