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Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet
Metabolism, 08/16/2012
Klempel MC et al. – These findings suggest that an Alternate day fasting (ADF)–high–fat (HF) diet is equally as effective as an ADF–LF diet in helping obese subjects lose weight and improve coronary heart disease (CHD) risk factors.
Methods- Thirty–two obese subjects were randomized to an ADF–HF (45% fat) or ADF–LF diet (25% fat), which consisted of two phases:
- A 2–week baseline weight maintenance period,
- And an 8–week ADF weight loss period.
- All food was provided during the study.
- Body weight was reduced (P<0.0001) by ADF–HF (4.8%±1.1%) and by ADF–LF (4.2%±0.8%).
- Fat mass decreased (P<0.0001) by ADF–HF (5.4±1.5kg) and ADF–LF (4.2±0.6kg).
- Fat free mass remained unchanged.
- Waist circumference decreased (P<0.001) by ADF–HF (7.2±1.5cm) and ADF–LF (7.3±0.9cm).
- LDL cholesterol and triacylglycerol concentrations were reduced (P<0.001) by both interventions (ADF–HF: 18.3%±4.6%, 13.7%±4.8%; and ADF–LF: 24.8%±2.6%, 14.3%±4.4%).
- HDL cholesterol, blood pressure, and heart rate remained unchanged.
- There were no between–group differences for any parameter.
