Alternative Markers of Hyperglycemia and Risk of Diabetes
Diabetes Care, 08/16/2012
Juraschek SP et al. – Fructosamine, glycated albumin, and 1,5–AG were associated with the subsequent development of diabetes independently of baseline A1C and fasting glucose. The results suggest these alternative biomarkers may be useful in identifying persons at risk for diabetes.Methods
- The authors used Cox proportional hazards models to examine the associations of fructosamine, glycated albumin, and 1,5-AG with incident diabetes in 1,299 participants, from the Atherosclerosis Risk in Communities (ARIC) Study (2005–2006), who had no history of diagnosed diabetes at baseline.
- Incident diabetes was self-reported during annual telephone calls.
- There were 119 new cases of diabetes during a median follow-up of 3.3 years.
- When compared with the lowest quartile, the fourth quartiles of fructosamine and glycated albumin were significantly associated with diabetes risk (hazard ratio [HR] 3.99 [95% CI 1.93-8.28] and 5.22 [2.49-10.94], respectively).
- The fourth quartile of 1,5-AG was associated with a significantly lower diabetes risk (0.27 [0.14-0.55]).
- Associations were attenuated but still significant after adjustment for hemoglobin A1c (A1C) or fasting glucose.